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PostPosted: 06 Nov 2021 14:38 
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The UK Govt. Press Release issued this week states:

The antiviral Lagevrio (molnupiravir) is safe and effective at reducing the risk of hospitalisation and death in people with mild to moderate COVID-19 who are at increased risk of developing severe disease, the Medicines and Healthcare products Regulatory Agency (MHRA) announced today.

This follows a rigorous review of its safety, quality and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, making it the first oral antiviral for the treatment of COVID-19 to be approved.

Developed by Ridgeback Biotherapeutics and Merck Sharp & Dohme (MSD), Lagevrio works by interfering with the virus’ replication. This prevents it from multiplying, keeping virus levels low in the body and therefore reducing the severity of the disease.

Based on the clinical trial data, Lagevrio is most effective when taken during the early stages of infection and so the MHRA recommends its use as soon as possible following a positive COVID-19 test and within five days of symptoms onset

Molnupiravir has been authorised for use in people who have mild to moderate COVID-19 and at least one risk factor for developing severe illness. Such risk factors include obesity, older age (>60 years), diabetes mellitus, or heart disease.

Dr June Raine, MHRA Chief Executive, said:
“Following a rigorous review of the data by our expert scientists and clinicians, we are satisfied that Lagevrio (molnupiravir) is safe and effective for those at risk of developing severe COVID-19 disease and have granted its approval.

“Lagevrio is another therapeutic to add to our armoury against COVID-19. It is also the world’s first approved antiviral for this disease that can be taken by mouth rather than administered intravenously. This is important, because it means it can be administered outside of a hospital setting, before COVID-19 has progressed to a severe stage.

“In clinical trials, Lagevrio was found to be effective in reducing the risk of hospitalisation or death for at-risk non-hospitalised adults with mild to moderate COVID-19 by 50%.

Lagevrio is not intended to be used as a substitute for vaccination against COVID-19.

Molnupiravir - will be given twice a day to vulnerable patients recently diagnosed with the disease. At the moment it costs $700/- per course


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PostPosted: 13 Nov 2021 13:48 
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Hi Badri
it is heartening to know that a true antiviral therapy and that too in a oral form has come at last. As noted in the last it is important to bear in the mind that vaccination in any case should not lag behind just because a therapy has come. One important aspect with the Covid 19 is that this virus has a knack of evading all our efforts to contain it. In Kerala there is a report in the newspapers that among the 7000 odd cases reported in one day there are more cases among the fully vaccinated ones than among the unvaccinated. This is really a matter of concern, isn't it? This may be due to complacency on the part of the vaccinated people in not wearing masks and attending social gatherings like family functions and other events. Even in gatherings of doctors i find many without masks. Among all the measures to keep Covid 19 out of reach, i think wearing mask properly and keeping social distancing are most important.

UA Kohammed


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PostPosted: 24 Nov 2021 19:44 
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Hi Mohammed,

Wearing a mask is really the best defence against the present pandemic. You will be surprised at the way the number of people in Europe, particularly among the young who are resistant to wearing a mask behave. One lot are against vaccination - they believe it is their fundamental right to choose what they do! However when they get they get infected they demand that the government do everything possible to get them out of trouble. I am sure you would have seen the news about the riots in Belgium and Austria when the govt introduced "Lock Down" as the infection rate is going up there. What do you do with all these people

Health care in UK is far from satisfactory at the moment. Waiting lists for routine surgery in NHS hospital has reached record levels. It is difficult to see a doctor for routine appointments. All this is because of the present pandemic. Number of new infections everyday is around 40,000 in UK today.


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