It is currently 02 Dec 2021 15:24

All times are UTC + 5:30 hours [ DST ]

Post new topic Reply to topic  [ 1 post ] 
Author Message
PostPosted: 31 May 2020 11:46 

Joined: 19 Dec 2017 14:21
Posts: 89
• The Arias-Stella reaction is a benign endometrial change due to hormonal effect. It was first described by Dr. Javier Arias-Stella in 1954. Also referred to as Arias Stella change
• It may be seen in pregnancy and postpartum
• It is characterized by hypertrophy and vacuolization of the cells of the endometrium, associated with marked nuclear pleomorphism, enlargement, and hyperchromasia.
• When it occurs in extra-uterine sites such as ovary, fallopian tubes, vagina and cervix, the differentiation of Arias-Stella changes from clear cell cancers in these locations can be challenging and the biopsy should be carefully examined to avoid misdiagnosis of cancer

• Pregnancy associated
• Oral contraceptive use especially progesterone
• Trophoblastic disease associated

Incidental finding
May present as endocervical polyp when it occurs in the cervix

Five histologic variants are recognized
• Minimal atypia - nuclear enlargement is minimal and occurs focally; usually at the start of pregnancy
• Early secretory pattern – Similar to normal early secretory endometrium with subnuclear or subnuclear / supranuclear vacuolation
• Secretory or hypersecretory pattern – Most common pattern; glandular cells with extensive cytoplasmic vacuolization; enlarged and hyperchromatic nuclei
• Regenerative, proliferative or nonsecretory pattern - Minimal evidence of secretory activity; enlarged vesicular nuclei
• Monstrous cell pattern - Usually occurs focally, with giant and bizarre nuclei, affecting all the glandular epithelial cells

• Clear cell adenocarcinoma
• Serous papillary carcinoma
• HPV associated endocervical adenocarcinoma
• Radiation or chemotherapy induced changes

Recognition of Arias-Stella reaction in extra-uterine locations, especially in young women, is important and to avoid a wrong diagnosis of clear cell adenocarcinoma. It is necessary to pay attention to cellular and nuclear detail and interpret the changes in the clinical context (pregnancy or other forms of hormonal stimulation).

Arias Stella changes disappear after pregnancy.

 Profile Send private message  
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 1 post ] 

All times are UTC + 5:30 hours [ DST ]

Who is online

Users browsing this forum: No registered users and 1 guest

You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot post attachments in this forum

Jump to: